Nicotinamide adenine dinucleotide (NAD+) plays a fundamental role in life and health through the regulation of energy biogenesis, redox homeostasis, cell metabolism, and the arbitration of cell survival via linkages to apoptosis and autophagic pathways. Apart from reducing the functions of mitochondria, biological changes such as cognitive impairments, DNA damage and sirtuin gene inactivation, are… Continue reading NAD+ for Healthspan, Long-term Cognition, and Energy
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Longevity and Long-term Cognition via Minimizing Chronic Inflammation
Chronic inflammation is central to the seven pillars of ageing. From the Cleveland Clinic: The most common reasons for chronic inflammation include: Autoimmune disorders, such as lupus, where your body attacks healthy tissue. Exposure to toxins, like pollution or industrial chemicals. Untreated acute inflammation, such as from an infection or injury. Some lifestyle factors also contribute to… Continue reading Longevity and Long-term Cognition via Minimizing Chronic Inflammation
Heart Health via a Whole-Food, Unprocessed, Plant-Based Diet
Heart health supports health span, brain health, and vitality. Here are a few suggestions. Eating a plant-based diet at any age may lower cardiovascular risk. People can choose among plant foods that are as close to natural as possible, not highly processed. More plant foods mean less risk. The most dangerous plaques go away… Continue reading Heart Health via a Whole-Food, Unprocessed, Plant-Based Diet
Longevity via a Whole-Food, Unprocessed, Plant-based Diet
People who improve the quality of their diets over time, eating more whole grains, vegetables, fruits, nuts, spices, and fish and less red and processed meats and sugary beverages, may significantly reduce their risk of premature death. Be aware that supermarket “whole grain bread” is not really whole grain. A whole-food plant-based diet (avoid… Continue reading Longevity via a Whole-Food, Unprocessed, Plant-based Diet
Magnesium for longevity, long-term cognition, and vitality
Magnesium (Mg2+) plays an important physiological role particularly in the brain, heart, and skeletal muscles. Moreover, Mg2+ supplementation has been shown to be beneficial in treatment of, among others, preeclampsia, migraine, depression, coronary artery disease, and asthma. Two doctors discuss magnesium and magnesium supplementation. From the Mayo Clinic: Many Americans don’t get enough magnesium in… Continue reading Magnesium for longevity, long-term cognition, and vitality
Long-term cognition via minimizing neuroinflammation
There is increasing evidence suggesting that chronic neuroinflammation is the most relevant pathological feature of Alzheimer’s disease (AD), regulating other pathological features, such as the accumulation of amyloid-β (Aβ) and hyperphosphorylation of Tau. Systemic inflammatory signals caused by systemic disorders are known to strongly influence neuroinflammation as a consequence of microglial activation, inflammatory mediator… Continue reading Long-term cognition via minimizing neuroinflammation
Long-term Cognition via a Healthy Lifestyle
Brain health is whole-person health. The idea that focusing on only one aspect of health, like diet or exercise, will result in a healthy older brain is naïve. We need to make sustained efforts across all aspects of wellness to remain cognitively vibrant into old age. Using data from the Chicago Health and Aging… Continue reading Long-term Cognition via a Healthy Lifestyle
Better Mood, Longer Life, and Mental Health via Avoiding Alcohol
Alcohol is an age-old nerve poison. Studies that show a slight health advantage to light drinking can never be done in isolation, so there are confounding factors such a socioeconomic status that may overcome the subject of study. Meta-analyses of alcohol consumption adjusting for these factors find that low-volume alcohol consumption has no net… Continue reading Better Mood, Longer Life, and Mental Health via Avoiding Alcohol
Long Term Cognition and Longevity via Intermittent Fasting
Intermittent fasting (IF) is supported by evolutionary principles. Dr. Mike Hansen explains the benefits of intermittent fasting here. From this illuminating video: Our bodies are designed to be in the fasted state 12-14 hours per day. Fasting does not begin for 5 hours after eating. Eating good food at the wrong time is akin to… Continue reading Long Term Cognition and Longevity via Intermittent Fasting
Longevity via Exercise
Exercise every day: no excuses! Here is why. Exercise plays an important role in the prevention, treatment, and rehabilitation of diseases, and is the basis of active and universal health. Exercise may be the best protection against ageing: it keeps the body decades younger. The most highly fit have the lowest risk of dying. We… Continue reading Longevity via Exercise