Autophagy for longevity and long-term cognition. Alcohol consumption is a cognitive, heart, and cancer Threat Blood Pressure control (below 120 systolic) to prevent dementia, for kidney health, for cardiovascular health. and for longevity Blood Sugar control for long-term cognition Blood-brain barrier dysfunction can precede symptoms of cognitive decline. Circadian Oscillation that is strong will bring… Continue reading List of blog posts
Author: Otto
I am a health enthusiast, engineer, and maker.
Mitochondrial Health
Every cell contains hundreds of mitochondria, each with its own genome, mitochondrial DNA separate from that of the cell nucleus. The primary role of mitochondria is to generate chemical energy store molecules, adenosine triphosphate (ATP), used to power cell activities. Mitochondrial dysfunction with aging isn’t just a loss of ATP generation and production of a harmful amount of reactive oxygen species, however. It… Continue reading Mitochondrial Health
Polyhenols for Healthspan and Long-term cognition
Health benefits of phenolic compounds From Medical News Today: Polyphenols may improve rheumatoid arthritis through mitogen-activated protein kinase (MAPK) inhibition. In addition, plant-derived polyphenols can reduce depression, inflammation, and oxidative stress. Quercetin and epicatechin (EC) decrease atherosclerosis by augmenting nitric oxide (NO) activity and decreasing serological endothelin-1 levels. Quercetin, which can be obtained from… Continue reading Polyhenols for Healthspan and Long-term cognition
The Incredible Danger of Sugar Overconsumption
Dr. Mike Hansen pointed out this systematic reviews and meta-analyses of randomised controlled trials. This included 73 meta-analyses and 83 health outcomes from 8601 unique articles, including 74 unique outcomes in meta-analyses of observational studies and nine unique outcomes in meta-analyses of randomised controlled trials. The results: Significant harmful associations between dietary sugar consumption and… Continue reading The Incredible Danger of Sugar Overconsumption
Long term Cognition via a healthy intact Blood-Brain Barrier
Dr. Rhonda Patrick explains the blood-brain barrier. Individuals with early cognitive dysfunction develop brain capillary damage and BBB breakdown in the hippocampus irrespective of Alzheimer’s Aβ and/or tau biomarker changes, suggesting that BBB breakdown is an early biomarker of human cognitive dysfunction independent of Aβ and tau. Here is a discussion about this paper.… Continue reading Long term Cognition via a healthy intact Blood-Brain Barrier
NAD+ for Healthspan, Long-term Cognition, and Energy
Nicotinamide adenine dinucleotide (NAD+) plays a fundamental role in life and health through the regulation of energy biogenesis, redox homeostasis, cell metabolism, and the arbitration of cell survival via linkages to apoptosis and autophagic pathways. All sirtuins are NAD+ dependent. This Healthline piece suggests that “Research in humans has shown that NMN in doses… Continue reading NAD+ for Healthspan, Long-term Cognition, and Energy
Longevity and Long-term Cognition via Minimizing Chronic Inflammation
Chronic inflammation is central to the seven pillars of ageing. From the Cleveland Clinic: The most common reasons for chronic inflammation include: Autoimmune disorders, such as lupus, where your body attacks healthy tissue. Exposure to toxins, like pollution or industrial chemicals. Untreated acute inflammation, such as from an infection or injury. Some lifestyle factors also contribute to… Continue reading Longevity and Long-term Cognition via Minimizing Chronic Inflammation
Heart Health via a Whole-Food, Unprocessed, Plant-Based Diet
Heart health supports health span, brain health, and vitality. Here are a few suggestions. Eating a plant-based diet at any age may lower cardiovascular risk. People can choose among plant foods that are as close to natural as possible, not highly processed. More plant foods mean less risk. The most dangerous plaques go away… Continue reading Heart Health via a Whole-Food, Unprocessed, Plant-Based Diet
Longevity via a Whole-Food, Unprocessed, Plant-based Diet
People who improve the quality of their diets over time, eating more whole grains, vegetables, fruits, nuts, spices, and fish and less red and processed meats and sugary beverages, may significantly reduce their risk of premature death. A whole-food plant-based diet (avoid (vegan) junk food) is the optimal diet for humans. A diet… Continue reading Longevity via a Whole-Food, Unprocessed, Plant-based Diet
Magnesium for longevity, long-term cognition, and vitality
Magnesium (Mg2+) plays an important physiological role particularly in the brain, heart, and skeletal muscles. Moreover, Mg2+ supplementation has been shown to be beneficial in treatment of, among others, preeclampsia, migraine, depression, coronary artery disease, and asthma. Two doctors discuss magnesium and magnesium supplementation. From the Mayo Clinic: Many Americans don’t get enough magnesium in… Continue reading Magnesium for longevity, long-term cognition, and vitality