Long Term Cognition via controlling Blood Sugar

Here are the dangers of high blood sugar:

Higher blood sugar means higher risk of dementia.

Blood sugar above 105 to 110 is a cognitive hazard.

High fasting glucose increases brain glucose and causes hippocampal atrophy.

High blood sugar→vascular dementia and other dementia

High fasting glucose causes whole brain atrophy.

Keep blood sugar low to avoid oxidative stress.

Even high-normal glucose shrinks the brain: keep blood sugar low!

Shown by a study of 240 healthy adults

Shown by a study of 266 men and women between the ages of 60 and 64.

Shown by 249 cognitively healthy non-diabetic individuals aged was 60-64.

Shown by a study of 210 cognitively healthy individuals (68–73 years).

Shown by a study of 2067 participants without dementia.

Shown by a study of 124 cognitively normal, non-diabetic adults with a family history of Alzheimer’s disease.

Shown by a study 249 people in their early 60s whose blood sugar was “high-normal”.

Shown by a study of 1,173 people, aged 75

Shown by a study of 2067 participants without dementia

Shown by a study of 5,189 people over 10 years.

Shown by a study of 104 healthy adults (ages 18 to 78) without diagnoses of diabetes or hypertension.

This even applies to those who are not prediabetic.

For those with stubbornly high blood sugar, Metformin might help. But Dr. Dale Bredesen suggests that lifestyle modification is vastly superior to medication for controlling blood sugar.

High after-meal (postprandial) blood glucose is a cognitive hazard.

Perturbed cerebral glucose metabolism is a feature of more severe Alzheimer’s.

Too much insulin can lead to neuroinflammation. Insulin is raised by eating sugar, and simple carbs.

Hyperglycemia results in reduced hippocampal microstructure.

Hyperglycemia increases amyloid-β levels.

Hyperglycemia increases susceptibility to amyloid-β toxicity.

High blood sugar results in abnormally low brain-derived neurotophic factor (BDNF).

High blood sugar injures via inhibition of MIF enzyme activity

Glycation (caused by high blood sugar) damages an enzyme called MIF (macrophage migration inhibitory factor).

Low blood sugar is also hazardous.

Hyperglycemia impairs neural activity in ways that are similar to what is observed in preclinical Alzheimer’s disease models.

 

By Otto

I am a health enthusiast, engineer, and maker.

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